. * * window.aa needs to exist and be usable by ANY module's script, * however early it runs - main-nav's script, for one, runs near * the top of

91探花

, well before the real search-insights.js * so the download * begins as early as before. Repeat calls share the same downloads, a * failed load is retried on the next call, and the versions / SRI * hashes live only here. * * Algolia Insights is unaffected: window.aa above is still created in * on every page and queues events until search-insights loads. * * window.loadAlgoliaLibs({ priority: 'high' }) (Oct 2026): used by the * /search page, where the first results wait on these libraries. Chrome * gives async scripts low priority, behind images and fonts; this asks * for high instead (fetchpriority). Only the first call for a library * sets its priority - later calls share that download. */ (function (win, doc) { var LIBS = [ { ready: function () { return !!win['algoliasearch/lite']; }, src: 'https://cdn.jsdelivr.net/npm/algoliasearch@5.52.1/dist/lite/builds/browser.umd.js', integrity: 'sha256-I2oYUIvhx1g6l4lTP+yoERbzLIHKzw4AKaBRQPwIeDY=' }, { ready: function () { return !!win.instantsearch; }, src: 'https://cdn.jsdelivr.net/npm/instantsearch.js@4.98.0/dist/instantsearch.production.min.js', integrity: 'sha256-ngmqZk4WBxUw257aMYZayyNBd983INngagv0jI6Ecfs=' } ]; function loadOne(lib, options) { if (lib.ready()) return Promise.resolve(); // One download per library, shared by every caller; reset on // failure so the next call retries just the library that failed. if (lib.pending) return lib.pending; lib.pending = new Promise(function (resolve, reject) { var script = doc.createElement('script'); script.src = lib.src; script.integrity = lib.integrity; script.crossOrigin = 'anonymous'; script.async = true; if (options && options.priority === 'high') script.setAttribute('fetchpriority', 'high'); script.onload = function () { lib.ready() ? resolve() : reject(new Error('Loaded but not available: ' + lib.src)); }; script.onerror = function () { script.remove(); reject(new Error('Could not load ' + lib.src)); }; doc.head.appendChild(script); }); lib.pending.catch(function () { lib.pending = null; }); return lib.pending; } win.loadAlgoliaLibs = function (options) { return Promise.all(LIBS.map(function (lib) { return loadOne(lib, options); })); }; })(window, document); . */ window.hsConversationsSettings = window.hsConversationsSettings || {}; window.hsConversationsSettings.loadImmediately = false; (function (win) { var EVENTS = ['pointerdown', 'keydown', 'touchstart', 'scroll', 'mousemove', 'wheel']; var done = false; /* 19 Oct 2026 - chat widget layout shift (field CLS). Phones fail Core Web Vitals on CLS (p75 ~0.2 site-wide in CrUX for months). Biggest cause found: HubSpot's chat container is fixed to the bottom-right corner and changes size - 100x96 launcher to 282x253 when the welcome message pops up (~5 s after load), and to full screen when a visitor opens the chat. Its top-left corner moves, so Chrome scores it as a layout shift: 0.088 per page view at 360x640 (0.044 at 412x850), on every page. Taps happen inside the chat iframe, so the parent page never sees the input and the open/close shifts count too. Fix: whenever the container's size changes it is made transparent for 400 ms (Chrome doesn't score shifts of invisible elements), then shown again at its new size. Tested on live io1001 at 360x640 in a cookie-less frame: the 0.088 shift no longer appears. The chat itself is unchanged - it just appears 0.4 s later at each resize. Relies on HubSpot's container id; if that changes this does nothing (no error). */ function cloakChatResizes() { var ID = 'hubspot-messages-iframe-container'; function watch(c) { if (c.getAttribute('data-bb-cloak')) return; c.setAttribute('data-bb-cloak', '1'); var last = c.offsetWidth + 'x' + c.offsetHeight, timer = null; new MutationObserver(function () { var size = c.offsetWidth + 'x' + c.offsetHeight; if (size === last) return; last = size; c.style.setProperty('opacity', '0', 'important'); clearTimeout(timer); timer = setTimeout(function () { c.style.removeProperty('opacity'); }, 400); }).observe(c, { attributes: true, attributeFilter: ['style', 'class'], subtree: true, childList: true }); } var found = document.getElementById(ID); if (found) { watch(found); return; } if (!document.body || !('MutationObserver' in win)) return; var mo = new MutationObserver(function () { var c = document.getElementById(ID); if (c) { mo.disconnect(); watch(c); } }); mo.observe(document.body, { childList: true }); setTimeout(function () { mo.disconnect(); }, 30000); } function loadWidget() { var api = win.HubSpotConversations; if (api && api.widget && api.widget.status && api.widget.status().loaded) return; try { cloakChatResizes(); } catch (e) {} if (api && api.widget) api.widget.load(); } function onFirstInteraction() { if (done) return; done = true; EVENTS.forEach(function (type) { win.removeEventListener(type, onFirstInteraction, { passive: true }); }); var start = function () { if (win.HubSpotConversations) loadWidget(); else (win.hsConversationsOnReady = win.hsConversationsOnReady || []).push(loadWidget); }; if ('requestIdleCallback' in win) win.requestIdleCallback(start, { timeout: 1500 }); else setTimeout(start, 200); } EVENTS.forEach(function (type) { win.addEventListener(type, onFirstInteraction, { passive: true }); }); })(window);

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Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
Webinar

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

This webinar explores the increasing implication of glial cells in neurodegenerative diseases making them an appealing addition to iPSC-based model systems for investigating disease mechanisms. Over the last decade, Dr. Fossati鈥檚 lab has developed robust and efficient protocols to generate human oligodendrocytes, astrocytes, microglia, neurons, and complex 3D organoid cultures with the full compendium of glia and neuronal cells. Investigating the crosstalk between neurons and glia allows for identification and targeting of glial-driven pathogenic mechanisms linked to neuroinflammation and neurodegeneration.
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Valentina Fossati, PhD

Senior Research Investigator

The New York Stem Cell Foundation

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

In锚s Ferreira

Senior Product Manager

91探花

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
This webinar explores the increasing implication of glial cells in neurodegenerative diseases making them an appealing addition to iPSC-based model systems for investigating disease mechanisms. Over the last decade, Dr. Fossati鈥檚 lab has developed robust and efficient protocols to generate human oligodendrocytes, astrocytes, microglia, neurons, and complex 3D organoid cultures with the full compendium of glia and neuronal cells. Investigating the crosstalk between neurons and glia allows for identification and targeting of glial-driven pathogenic mechanisms linked to neuroinflammation and neurodegeneration.
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Valentina Fossati, PhD

Senior Research Investigator

The New York Stem Cell Foundation

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

In锚s Ferreira

Senior Product Manager

91探花

As neurodegenerative diseases continue to impact millions, researchers are increasingly exploring the role of glial cells in CNS health and disease. Could specific glial cell behaviours drive the progression of diseases like multiple sclerosis or Alzheimer鈥檚? 

Watch this insightful webinar featuring Dr. Valentina Fossati, Senior Research Investigator at the New York Stem Cell Foundation, and In锚s Ferreira, Senior Product Manager at 91探花.

Dr. Fossati will highlight how adding glial cells into human iPSC-derived models contributes to our understanding of disease mechanisms.

In锚s Ferreira will share findings from a collaboration with Charles River Laboratories, focusing on complex models utilising ioOligodendrocyte-like cells, ioMicroglia, and ioGlutamatergic Neurons to study neuroinflammation and neurodegeneration.

Key learning points: 

  • Discover the critical roles of glial cells in CNS diseases
  • Learn about methods for developing human glial cell models
  • Explore how human models reveal intrinsic phenotypes of multiple sclerosis
  • Learn how ioCells can be used in complex cell models to study neurodegeneration

 

For accessing webinar, please fill out the form below.

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