• 91探花 launches ioSkeletal Myocytes鈩� the first supply of consistent, scalable, human muscle cells provide transformative new models for research and drug discovery
• Highly consistent and scalable supply of lab grown human skeletal muscle cells provide an effective and biologically relevant tool for research and drug development in conditions as diverse as metabolic and muscle diseases and ageing.

91探花 has today launched a new product, ioSkeletal Myocytes. It鈥檚 the first product of its kind that provides physiologically relevant human skeletal muscle cells that are reliable, reproducible and consistent at scale. Access to ioSkeletal Myocytes will supercharge research and drug discovery for musculoskeletal and metabolic conditions.

ioSkeletal Myocytes can be used within days after thawing, affording scientists unprecedented ease and consistency for their experiments. ioSkeletal Myocytes are created through direct reprogramming of human iPSCs (induced pluripotent stem cells) using 91探花鈥檚 breakthrough cell coding technology 辞辫迟颈-辞虫鈩�. They are the second 鈥榦ff the shelf鈥� cell type product from 91探花 and form part of the expanding ioCells portfolio.

鈥淭his second product is another validation of 91探花鈥檚 approach to biology as the next disruptive technology. When you give scientists access to reliable human cells the only limit to the questions they can ask and the experiments they can design is their imagination. And we are already seeing that imagination unleashed in the diverse ways our partners are using our cells. Each ioCell will open up a whole new product line in the form of disease models, providing even greater research opportunities. Building out our ioCell portfolio is a core pillar of 91探花鈥檚 strategy, next to developing 91探花鈥檚 cells for therapeutic applications. Together, this will enable the next generation of medicines.鈥�

Mark KotterCo-founder and CEO, 91探花

ioSkeletal Myocytes have been validated by 91探花鈥檚 partners in different applications, a key stage in the development of the product. One partner, Charles River Laboratories, a provider of products and services that help expedite the discovery, early-stage development and safe manufacture of novel drugs and therapeutics, has adopted 91探花鈥檚 ioSkeletal Myocytes into its discovery offering, including high-throughput screening (HTS) workflows.

鈥淧reviously, acquiring skeletal myocytes for research has either been from animal models, which do not always behave like human muscle cells, or by using primary human cells with methods that produce only small cell quantities. We have seen first-hand that ioSkeletal Myocytes eliminate this cumbersome, time-consuming process, and quickly provide reliable and consistent access to large quantities of human myocytes, which can be used for high-throughput screening.鈥�

Dr Marijn VlamingHead of Biology - Leiden Beerse | Charles River Laboratories

The product provides functional and consistent human cells which can be used to study the physiology of human skeletal muscle cells and their response to potential drug candidates.

91探花鈥檚 human ioSkeletal Myocytes will increase translatability of research findings so can play a significant role in reducing the average cost and time spent on drug development and increase the chances of new treatments making it through the clinic and to patients.

ioSkeletal Myocytes are launching ahead of a 91探花 workshop at 'The European Laboratory Research & Innovation Group (ELRIG) drug discovery conference 2021' where speakers Dr Luckshman Jeremy Anton (Charles River Laboratories), Prof Michael Duchen (University College London) and Prof Hagan Bayley (University of Oxford) will discuss the challenges of cell models and novel approaches and tools for basic research and drug discovery that include 91探花鈥檚 cells.

ioSkeletal Myocytes are available through 91探花 and affiliated distributions to the greater academic and biotech communities