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, well before the real search-insights.js * so the download * begins as early as before. Repeat calls share the same downloads, a * failed load is retried on the next call, and the versions / SRI * hashes live only here. * * Algolia Insights is unaffected: window.aa above is still created in * on every page and queues events until search-insights loads. * * window.loadAlgoliaLibs({ priority: 'high' }) (Oct 2026): used by the * /search page, where the first results wait on these libraries. Chrome * gives async scripts low priority, behind images and fonts; this asks * for high instead (fetchpriority). Only the first call for a library * sets its priority - later calls share that download. */ (function (win, doc) { var LIBS = [ { ready: function () { return !!win['algoliasearch/lite']; }, src: 'https://cdn.jsdelivr.net/npm/algoliasearch@5.52.1/dist/lite/builds/browser.umd.js', integrity: 'sha256-I2oYUIvhx1g6l4lTP+yoERbzLIHKzw4AKaBRQPwIeDY=' }, { ready: function () { return !!win.instantsearch; }, src: 'https://cdn.jsdelivr.net/npm/instantsearch.js@4.98.0/dist/instantsearch.production.min.js', integrity: 'sha256-ngmqZk4WBxUw257aMYZayyNBd983INngagv0jI6Ecfs=' } ]; function loadOne(lib, options) { if (lib.ready()) return Promise.resolve(); // One download per library, shared by every caller; reset on // failure so the next call retries just the library that failed. if (lib.pending) return lib.pending; lib.pending = new Promise(function (resolve, reject) { var script = doc.createElement('script'); script.src = lib.src; script.integrity = lib.integrity; script.crossOrigin = 'anonymous'; script.async = true; if (options && options.priority === 'high') script.setAttribute('fetchpriority', 'high'); script.onload = function () { lib.ready() ? resolve() : reject(new Error('Loaded but not available: ' + lib.src)); }; script.onerror = function () { script.remove(); reject(new Error('Could not load ' + lib.src)); }; doc.head.appendChild(script); }); lib.pending.catch(function () { lib.pending = null; }); return lib.pending; } win.loadAlgoliaLibs = function (options) { return Promise.all(LIBS.map(function (lib) { return loadOne(lib, options); })); }; })(window, document); . */ window.hsConversationsSettings = window.hsConversationsSettings || {}; window.hsConversationsSettings.loadImmediately = false; (function (win) { var EVENTS = ['pointerdown', 'keydown', 'touchstart', 'scroll', 'mousemove', 'wheel']; var done = false; /* 19 Oct 2026 - chat widget layout shift (field CLS). Phones fail Core Web Vitals on CLS (p75 ~0.2 site-wide in CrUX for months). Biggest cause found: HubSpot's chat container is fixed to the bottom-right corner and changes size - 100x96 launcher to 282x253 when the welcome message pops up (~5 s after load), and to full screen when a visitor opens the chat. Its top-left corner moves, so Chrome scores it as a layout shift: 0.088 per page view at 360x640 (0.044 at 412x850), on every page. Taps happen inside the chat iframe, so the parent page never sees the input and the open/close shifts count too. Fix: whenever the container's size changes it is made transparent for 400 ms (Chrome doesn't score shifts of invisible elements), then shown again at its new size. Tested on live io1001 at 360x640 in a cookie-less frame: the 0.088 shift no longer appears. The chat itself is unchanged - it just appears 0.4 s later at each resize. Relies on HubSpot's container id; if that changes this does nothing (no error). */ function cloakChatResizes() { var ID = 'hubspot-messages-iframe-container'; function watch(c) { if (c.getAttribute('data-bb-cloak')) return; c.setAttribute('data-bb-cloak', '1'); var last = c.offsetWidth + 'x' + c.offsetHeight, timer = null; new MutationObserver(function () { var size = c.offsetWidth + 'x' + c.offsetHeight; if (size === last) return; last = size; c.style.setProperty('opacity', '0', 'important'); clearTimeout(timer); timer = setTimeout(function () { c.style.removeProperty('opacity'); }, 400); }).observe(c, { attributes: true, attributeFilter: ['style', 'class'], subtree: true, childList: true }); } var found = document.getElementById(ID); if (found) { watch(found); return; } if (!document.body || !('MutationObserver' in win)) return; var mo = new MutationObserver(function () { var c = document.getElementById(ID); if (c) { mo.disconnect(); watch(c); } }); mo.observe(document.body, { childList: true }); setTimeout(function () { mo.disconnect(); }, 30000); } function loadWidget() { var api = win.HubSpotConversations; if (api && api.widget && api.widget.status && api.widget.status().loaded) return; try { cloakChatResizes(); } catch (e) {} if (api && api.widget) api.widget.load(); } function onFirstInteraction() { if (done) return; done = true; EVENTS.forEach(function (type) { win.removeEventListener(type, onFirstInteraction, { passive: true }); }); var start = function () { if (win.HubSpotConversations) loadWidget(); else (win.hsConversationsOnReady = win.hsConversationsOnReady || []).push(loadWidget); }; if ('requestIdleCallback' in win) win.requestIdleCallback(start, { timeout: 1500 }); else setTimeout(start, 200); } EVENTS.forEach(function (type) { win.addEventListener(type, onFirstInteraction, { passive: true }); }); })(window);

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91探花 to showcase its ioCRISPR-Ready Cells鈩笍 products at SLAS 2024

30.01.2024 | Published by 91探花

91探花 to showcase its ioCRISPR-Ready Cells鈩笍 products at SLAS 2024

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  • Poster presentations will include data from two products, highlighting 91探花鈥檚 recently launched CRISPR-Ready ioGlutamatergic NeuronsTM as well as the next product in the range - CRISPR-Ready ioMicrogliaTM.

  • 91探花 will host an expert panel discussion on the important role of functional genomics in early drug discovery, including the urgent need for predictive models in target identification and the challenges faced across different therapeutic areas, as well as the trade-offs involved in using different cell models for CRISPR screening.

  • CRISPR-Ready ioGlutamatergic Neurons shortlisted for the SelectScience 鈥淏est New Drug Discovery & Development Product鈥�.

CAMBRIDGE, UK, 08:00, 30 January 2024 - 91探花, the company coding human cells for novel cures, will showcase recent data and important applications of its new portfolio of ioCRISPR-Ready Cells at the Society for Laboratory Automation and Screening (SLAS) conference. SLAS will take place from 3-7 February 2024 at the Boston Convention and Exhibition Center. 

"With our ioCRISPR-Ready Cells, we're providing scientists with a powerful functional genomics tool to study any gene of interest in a defined human iPSC-derived cell system. Gene knockout experiments such as CRISPR screens that would previously require substantial time and specialised skills can now be undertaken in weeks by scientists with all levels of experience. We are excited to share these data at SLAS and to discuss the tremendous potential that this product range offer."

Farah Patell-Socha
Farah Patell-SochaR91探花 VP Research 91探花

At SLAS, the team will present posters on two ioCRISPR-Ready Cells products, confirming their ease-of-use and that they generate readouts within days using a simple protocol for cell maturation and guide RNA delivery: 

  • CRISPR-Ready ioGlutamatergic Neurons: a functional genomics tool to easily generate disease-specific models for drug discovery and development. Poster Session C, Tuesday 6 February, 12-1pm. Track: Assay Development and Screening. This product was launched by 91探花 in October 2023. 
  • CRISPR knockout screening for drug target identification and validation using CRISPR-Ready ioMicroglia. Poster Session D, Tuesday 6 February, 2-3pm. Track: Cellular Technologies. This is the next product in the ioCRISPR-Ready Cells range that will launch in 2024. 

ioCRISPR-Ready Cells are iPSC-derived human cells containing a constitutively-expressed Cas9 nuclease. They arrive ready-to-use and with simple protocols, allowing high gene knockout efficiencies and functional experimental readouts in a physiological relevant cellular model in days, significantly reducing experimental timelines. ioCRISPR-Ready Cells can also be scaled to high-throughput pooled or arrayed CRISPR screens. Potential applications include functional genomics, disease model generation, drug target identification and fundamental human biology research. 

All 91探花 ioCellsTM products, including ioCRISPR-Ready Cells, are precision reprogrammed using 91探花鈥檚 opti-oxTM technology. As such they are defined human cells that have inherent experimental scalability, offer unparallelled consistency and are simple to handle and culture.

At SLAS, 91探花 will host an expert panel discussion on the vital role of functional genomics in early drug discovery. The panel discussion will cover the urgent need for predictive models in target identification, specific challenges across different fields such as oncology and neuroscience, and the trade-offs involved in using different cell models and different techniques for CRISPR screening. 

Speakers: 
  • Rob Howes, PhD - Head of Discovery Sciences UK at Charles River Laboratories
  • Davide Gianni, PhD - Senior Director Functional Genomics, Discovery Sciences, BioPharmaceuticals R&D at AstraZeneca
  • Josh Tycko, PhD - Research Fellow in Neurobiology at Harvard Medical School
  • Ann Byrne, PhD - Functional Genomics, Business Development Manager at 91探花

Date and time: Tuesday 6th February 8:30am - 10:00am ET, room 104B 

CRISPR-Ready ioGlutamatergic NeuronsTM have been shortlisted for the SelectScience 鈥淏est New Drug Discovery & Development Product鈥�. The winner will be announced at SLAS. 

The 91探花 stand and members of the team will be at location 881 in the exhibition hall. 

To arrange interviews at SLAS with Farah Patell-Socha, VP research products, 91探花, please contact:

Chris Hempel

Spark Public Relations

chris.hempel@sparkpr.com

+1-775-813-0285

 

 

 

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